Transcriptional phenotype of B cells infiltrating lung cancer tumors has been characterized depending on the B-cell receptor isotype expression (IgA/IgG)
An article by researchers from the Institute of Bioorganic Chemistry has been published in Frontiers in Immunology, dedicated to the study of B-lymphocytes infiltrating lung and kidney tumors. For the first time, the scientists demonstrated that in patients with lung adenocarcinoma a subpopulation of memory B cells expressing membrane IgA is characterized by increased expression of FCRL4, PD-1, and RUNX2 — markers of chronic antigen stimulation and functional exhaustion. Analysis of TCGA data showed that a high level of FCRL4 expression is associated with poorer patient survival. The study expands our current understanding of the role of B cells in tumors and may contribute to the development of immunotherapy approaches aimed at restoring B-cell activity.
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- The Future Technologies Award “VYZOV” in the “Breakthrough” category has been awarded to Ilia Yampolsky
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XII.15 For deciphering the molecular mechanisms of bioluminescence and creating glowing plants
- Identification of animal venoms by Raman spectroscopy combined with principal component analysis
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XI.11 Scientists from the Department of Molecular Neuroimmune Signaling of the Institute of Bioorganic Chemistry RAS, together with colleagues from the Prokhorov General Physics Institute RAS using Raman spectroscopy carried out a comparative analysis of various animal venoms and a number of different nature substances (not-venoms), and the applicability of this method for the identification of animal venoms was demonstrated.
- Biotechnologies based on the fungal bioluminescence pathway
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XI.10 The journal Trends in Biotechnology published a review devoted to biotechnologies based on the fungal bioluminescence pathway (FBP). Unlike luminescent reporter systems that require the addition of a substrate, FBP uses the natural metabolite caffeic acid to maintain continuous, autonomous luminescence. This allows for the production of autonomously luminescent living organisms and overcomes the key limitations of previous technologies. The review examines recent advances in the creation of luminescent plants and FBP-based biosensors and discusses the potential applications of this reporter system in science and the economy.