Scientists from IBCh RAS and colleagues clarify the structural basis of thanatin-like antimicrobial peptide activity
Scientists from IBCh RAS and their colleagues investigated Rip-2, a natural thanatin-like antimicrobial peptide from the bean bug Riptortus pedestris, and found that its enhanced activity may depend on its C-terminal phenylalanine residue. Selection of E. coli clones with reduced Rip-2 susceptibility identified an R76C substitution in LptA, a component of the lipopolysaccharide transport system. Peptide mutagenesis, analysis of natural homologs, and structure-guided modeling allowed the authors to propose a testable model in which Rip-2 Phe18 contributes to LptA-dependent target engagement. The study clarifies the mechanism of action of thanatin-like peptides and may guide the rational design of new antibiotics. Learn more
News 
- Scientists from IBCh RAS and colleagues clarify the structural basis of thanatin-like antimicrobial peptide activity
science news
X.8 Researchers from the Shemyakin-Ovchinnikov Institute of bioorganic chemistry of the Russian Academy of Sciences and their colleagues studied Rip-2, a natural antimicrobial peptide from the bean bug Riptortus pedestris. This β-hairpin peptide is a more active natural homolog of thanatin, a well-known antimicrobial peptide from the predatory stink bug Podisus maculiventris. Such molecules are considered promising antibiotic prototypes against Gram-negative bacteria because they target the Lpt system, which is responsible for lipopolysaccharide transport and outer-membrane formation.
- Scientists from IBCH RAS and their colleagues propose a way to tell reliable immune recognition data from faulty records
science news
IX.22 A T cell recognizes a diseased cell by a molecular “tag” on its surface, and which T cell receptor fits which tag now shapes the development of cellular cancer therapies, vaccines and diagnostics. The world’s databases collecting these matches have turned out to be less dependable than was assumed: an independent experimental screen confirmed only about half of their entries. Scientists from IBCH RAS and their colleagues have shown how to tell sound records from faulty ones — and that the situation is markedly better than it might have seemed. The work is published in Nature Methods.
- School for Young Scientists: "Objects and Methods of Developmental Biology: Genomic, Molecular, and Morphogenetic Mechanisms of Development and Regeneration"
conferences
IX.4 From September 24-27, 2026, the Koltsov Institute of Developmental Biology of the Russian Academy of Sciences will host a school for young scientists entitled "Objects and Methods of Developmental Biology: Genomic, Molecular, and Morphogenetic Mechanisms of Development and Regeneration." The school is dedicated to the 150th anniversary of the birth of the eminent embryologist D.P. Filatov (1876–1943). It is supported by the Russian Science Foundation (grant no. 23-74-30005). Venue: IBD RAS (Moscow, 26 Vavilova St.).
Events 
- Open seminar of the Department of Immunology
science news
VI.8 (This event is over) Dear colleagues! On June 8 (Monday) at 3 p.m., an open seminar of the Department of Immunology will be held in seminary room 404 (4th floor, 52nd building), dedicated to the pre-defense of the dissertation for the degree of Candidate of Biological Sciences Anastasia I. Palamarchuk on the topic: "Overexpression of the telomerase catalytic subunit gene as a factor influencing the transcriptional and functional activity of NK cells, as well as their sensitivity to targeted elimination", specialty 1.5.3. Molecular Biology. Everyone is invited to attend. June 8th

